Thiotepa

Thiotepa

SCHEMBL4760

S=P(N1CC1)(N1CC1)N1CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 1/20 1.00
LMNA P02545 1/20 1.00
CHRM2 P08172 1/20 1.00
CYP3A4 P08684 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD2 P14416 1/20 1.00
HPGD P15428 1/20 1.00
ADRA2B P18089 1/20 1.00
ADRA2C P18825 1/20 1.00
CHRM3 P20309 1/20 1.00
CYP2B6 P20813 1/20 1.00
SLC6A2 P23975 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00
SLC6A4 P31645 1/20 1.00
ADRA1A P35348 1/20 1.00
HRH1 P35367 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31153244 0.86 LMNA (0.73) ABCB11LMNACHRM2CYP3A4ADRA2A
SCHEMBL3084917 0.84 ABCB11 (0.71) ABCB11LMNACHRM2CYP3A4ADRA2A
Tepa SCHEMBL7918394 0.83 ABCB11 (0.69) ABCB11LMNACHRM2CYP3A4ADRA2A
SCHEMBL11392242 0.75 ABCB11 (0.59) ABCB11LMNACHRM2CYP3A4ADRA2A
SCHEMBL433171 0.67
SCHEMBL436275 0.60 GLA (0.42) ABCB11LMNACHRM2CYP3A4ADRA2A
SCHEMBL992305 0.37 ALPG (0.31)
SCHEMBL277895 0.37 ALPG (0.31)
SCHEMBL29357 0.37 ALPG (0.31)
SCHEMBL28461987 0.37 ALPG (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 124557 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
CN-122081656-A Method for recycling valuable metals from waste lithium batteries 2026-05-26 CN claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
US-20260137678-A1 METHODS FOR TREATING OR PREVENTING NEUROENDOCRINE TUMOR FORMATION USING XPO1 INHIBITORS MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2026-05-21 US claimed
WO-2026107377-A1 PHARMACOLOGICAL RE-ACTIVATION OF MUTANT PVHL KARANICOLAS JOHN (US) 2026-05-21 WO claimed
US-20260137700-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE SK BIOPHARMACEUTICALS CO LTD (KR) 2026-05-21 US claimed
US-20260137794-A1 LIGAND-DRUG CONJUGATE AND USE THEREOF SYSTIMMUNE INC (US) 2026-05-21 US claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
US-20260139071-A1 Subcutaneous Formulations Of Anti-CD38 Antibodies And Their Uses JANSSEN BIOTECH INC (US) 2026-05-21 US claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
US-4766149-A SYNERGISTIC MIXTURE WITH ANTITUMOR AND ANTICARCINOGENIC AGENTS STIFTUNG DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) 1988-08-23 US claimed
EP-0273754-A2 Method of enhancing the biodistribution of antibody for localization in lesions CITY OF HOPE NATIONAL MEDICAL CENTER (US) 1988-07-06 EP claimed
US-4654585-A Phase detection method HEWLETT-PACKARD COMPANY (US) 1987-03-31 US claimed
EP-0140255-A2 Sustained-release injections SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1985-05-08 EP claimed
EP-0139286-A2 Prolonged sustained-release preparations SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1985-05-02 EP claimed
EP-0120907-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY Aston Molecules Limited (GB) 1984-10-10 EP claimed
WO-1984001506-A1 PHARMACEUTICAL PREPARATIONS FOR USE IN ANTITUMOUR THERAPY UNIV BIRMINGHAM (GB) 1984-04-26 WO claimed
EP-0019167-B1 MEDICINAL PREPARATION FOR THE TREATMENT OF CARCINOMA AND PROCESS FOR PREPARING IT Limburg, Hans, Dr. (DE) 1983-10-12 EP claimed
EP-0014437-A2 Novel 1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation and pharmaceutical compositions containing them SCHERING CORPORATION (US) 1980-08-20 EP claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed