Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757863 | 0.87 | NUDT1 (0.35) | NPC1RAB9AMAPTSMN1; SMN2JAK2 | |
| SCHEMBL4709570 | 0.84 | KDM4E (0.38) | NPC1RAB9AMAPTSMN1; SMN2JAK2 | |
| SCHEMBL5453382 | 0.83 | KDM4E (0.37) | NPC1RAB9AMAPTSMN1; SMN2JAK2 | |
| SCHEMBL4759759 | 0.73 | JAK2 (0.35) | JAK2JAK3NUDT1 | |
| SCHEMBL13841918 | 0.70 | KDM4E (0.49) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5741027 | 0.70 | SMPD3 (0.50) | JAK2JAK3NUDT1 | |
| SCHEMBL13841874 | 0.69 | PIK3CG (0.51) | NPC1RAB9AMAPTSMN1; SMN2JAK2 | |
| SCHEMBL3703475 | 0.69 | JAK2 (0.55) | NPC1MAPTJAK2JAK3NPSR1 | |
| Hydrochloric Acid SCHEMBL3022279 | 0.68 | NPC1 (0.36) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL12145626 | 0.67 | TSHR (0.47) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | Brystol-Myers Squibb Company (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038314-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-05 | — | — | WO | claimed |