Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.35 |
| ▸ | JAK3 | P52333 | 16/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757863 | 0.73 | NUDT1 (0.35) | JAK2JAK3NUDT1 | |
| SCHEMBL4760688 | 0.73 | NPC1 (0.41) | JAK2JAK3NUDT1 | |
| SCHEMBL4709570 | 0.71 | KDM4E (0.38) | JAK2JAK3NUDT1 | |
| SCHEMBL5453382 | 0.70 | KDM4E (0.37) | JAK2JAK3 | |
| SCHEMBL5741027 | 0.62 | SMPD3 (0.50) | JAK2JAK3NUDT1 | |
| SCHEMBL20295422 | 0.62 | CCNE1 (0.31) | — | |
| SCHEMBL19766651 | 0.60 | NUDT1 (0.41) | JAK2JAK3NUDT1 | |
| SCHEMBL3427015 | 0.59 | JAK2 (0.56) | JAK2JAK3 | |
| SCHEMBL1673128 | 0.59 | — | — | |
| SCHEMBL5474572 | 0.59 | NUDT1 (0.43) | JAK2JAK3NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | Brystol-Myers Squibb Company (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038314-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-05 | — | — | WO | claimed |