Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453382 | 0.98 | KDM4E (0.37) | KDM4ESRCALDH1A1HPGDFYN | |
| SCHEMBL4757863 | 0.88 | NUDT1 (0.35) | KDM4EALDH1A1HPGDKDRKMT2A | |
| SCHEMBL4760688 | 0.84 | NPC1 (0.41) | KDM4ESRCALDH1A1HPGDEGFR | |
| SCHEMBL4759759 | 0.71 | JAK2 (0.35) | JAK2JAK3NUDT1 | |
| SCHEMBL3703475 | 0.67 | JAK2 (0.55) | NPSR1JAK2JAK3NPC1MAPT | |
| SCHEMBL13841956 | 0.65 | MAPT (0.52) | KDM4EALDH1A1HPGDKDRPLK4 | |
| SCHEMBL19766651 | 0.65 | NUDT1 (0.41) | KDM4EALDH1A1HPGDLMNATSHR | |
| SCHEMBL5741027 | 0.64 | SMPD3 (0.50) | MAP4K4JAK2JAK3NUDT1 | |
| SCHEMBL615165 | 0.63 | ACHE (0.50) | KDM4EALDH1A1HPGDLMNAMAPK1 | |
| SCHEMBL25333334 | 0.63 | MAT2A (0.51) | ALDH1A1MAPK14CYP1A2CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | Brystol-Myers Squibb Company (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038314-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-05 | — | — | WO | claimed |