Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.36 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | DDO | Q99489 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692076 | 0.68 | ALDH1A1 (0.41) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL10208596 | 0.64 | KDM4E (0.48) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL19377738 | 0.64 | AXL (0.40) | KDM4EHSD17B10ALDH1A1HIF1ANGAA | |
| SCHEMBL30612395 | 0.62 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL11054514 | 0.62 | HCAR1 (0.38) | KDM4EALDH1A1KMT2AEPHX2 | |
| SCHEMBL21785477 | 0.62 | AXL (0.38) | KDM4EHSD17B10ALDH1A1HIF1ANGAA | |
| Hydrochloric Acid SCHEMBL11452778 | 0.61 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL15486621 | 0.61 | KDM4E (0.48) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL925044 | 0.60 | KDM4E (0.64) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL924129 | 0.60 | HSD17B10 (0.51) | KDM4EHSD17B10ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |