Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | IGF1R | P08069 | 2/20 | 0.81 |
| ▸ | GABRP | O00591 | 3/20 | 0.78 |
| ▸ | GABRD | O14764 | 3/20 | 0.78 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.78 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.78 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.78 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.78 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.78 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.78 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.78 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.78 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.78 |
| ▸ | GABRE | P78334 | 3/20 | 0.78 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.78 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.78 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.78 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13896412 | 0.87 | GABRP (1.00) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL26090898 | 0.86 | RAB9A (0.76) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL13896416 | 0.85 | NPC1 (0.74) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL30712063 | 0.83 | NPC1 (0.71) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL7722990 | 0.82 | NPC1 (0.69) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL3123492 | 0.82 | GABRP (0.74) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL31060147 | 0.81 | POLB (0.73) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL7719104 | 0.81 | NPC1 (0.67) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL30712070 | 0.80 | GABRP (0.72) | RAB9ANPC1POLBIGF1RGABRP | |
| SCHEMBL18229454 | 0.80 | POLB (0.70) | RAB9ANPC1POLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853254-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853254-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853254-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130184276-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130184276-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130184276-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-8314256-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314256-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314256-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-20 | — | — | US | disclosed |
| CN-101312722-A | Modulators of atp-binding cassette transporters | VERTEX PHARMA (US) | 2008-11-26 | — | — | CN | disclosed |
| EP-1933831-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| US-20070238775-A1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2007-10-11 | — | — | US | disclosed |
| US-20070238775-A1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2007-10-11 | — | — | US | disclosed |
| US-20070238775-A1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2007-10-11 | — | — | US | disclosed |
| WO-2007044560-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044560-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238775-A1 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | RAB9A 2302/4885NPC1 29/4885POLB 1617/4885 |
| US-20130184276-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | RAB9A 2302/4885NPC1 29/4885POLB 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.