Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761824 | 0.93 | POLB (0.49) | POLBMEN1MAPTKMT2ASLC6A7 | |
| SCHEMBL4762861 | 0.87 | ALDH1A1 (0.64) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL4762542 | 0.86 | HSD11B1 (0.53) | MAPTSLC6A7ALDH1A1GAAGPBAR1 | |
| SCHEMBL4762664 | 0.86 | POLB (0.56) | POLBMEN1MAPTKMT2ASLC6A7 | |
| SCHEMBL4761369 | 0.86 | POLB (0.52) | POLBMEN1MAPTKMT2ASLC6A7 | |
| SCHEMBL8245894 | 0.85 | POLB (0.47) | POLBMEN1MAPTKMT2ASLC6A7 | |
| SCHEMBL8239707 | 0.85 | ALDH1A1 (0.46) | POLBMEN1MAPTKMT2ASLC6A7 | |
| SCHEMBL4764201 | 0.82 | POLB (0.49) | POLBMEN1MAPTKMT2ASLC6A7 | |
| SCHEMBL8246475 | 0.82 | ALDH1A1 (0.58) | POLBMAPTSLC6A7ALDH1A1KDM4E | |
| SCHEMBL4763187 | 0.82 | SMN1; SMN2 (0.55) | MEN1MAPTKMT2ASLC6A7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907363-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | Bayer HealthCare AG (DE) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |