Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246475 | 0.90 | ALDH1A1 (0.58) | SMN1; SMN2PARP14PARP10SLC6A7ALDH1A1 | |
| SCHEMBL4764201 | 0.90 | POLB (0.49) | KMT2ASLC6A7MEN1LMNATSHR | |
| SCHEMBL4762664 | 0.90 | POLB (0.56) | PARP14PARP10KMT2ASLC6A7MEN1 | |
| SCHEMBL4761143 | 0.87 | SLC6A7 (0.49) | KMT2ASLC6A7MEN1LMNATSHR | |
| SCHEMBL4761369 | 0.86 | POLB (0.52) | PARP14PARP10KMT2ASLC6A7MEN1 | |
| SCHEMBL8245894 | 0.85 | POLB (0.47) | SMN1; SMN2MAPK1USP2KMT2ASLC6A7 | |
| SCHEMBL4762716 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1KMT2ASLC6A7MEN1 | |
| SCHEMBL8250759 | 0.83 | ALDH1A1 (0.57) | SMN1; SMN2PARP14PARP10KMT2ASLC6A7 | |
| SCHEMBL4761009 | 0.83 | MEN1 (0.56) | SMN1; SMN2MAPK1KMT2AMEN1LMNA | |
| SCHEMBL8239706 | 0.82 | POLB (0.43) | SMN1; SMN2KMT2ASLC6A7MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907363-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | Bayer HealthCare AG (DE) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |