Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138594 | 0.72 | EPHX2 (0.56) | EPHX2FAAHALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL27845477 | 0.71 | EPHX2 (0.54) | EPHX2FAAHALDH1A1TSHR | |
| SCHEMBL11447009 | 0.69 | POLB (0.53) | EPHX2JAK2JAK1JAK3GRIN2D | |
| SCHEMBL7980459 | 0.69 | EPHX2 (0.58) | EPHX2ALDH1A1TSHR | |
| SCHEMBL1074612 | 0.67 | EPHX2 (0.39) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18196867 | 0.67 | CNR2 (0.39) | EPHX2JAK2JAK1JAK3FAAH | |
| SCHEMBL4762436 | 0.66 | JAK2 (0.44) | EPHX2JAK2JAK1JAK3 | |
| SCHEMBL4762760 | 0.66 | JAK2 (0.31) | JAK2JAK1JAK3 | |
| SCHEMBL4761600 | 0.66 | JAK2 (0.44) | EPHX2JAK2JAK1JAK3 | |
| SCHEMBL21309807 | 0.66 | PGR (0.45) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966200-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | Astellas Pharma Inc. (JP) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007077949-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-07-12 | — | — | WO | disclosed |