Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763636 | 0.93 | CRHR1 (0.56) | CRHR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4770391 | 0.92 | CRHR1 (0.53) | CRHR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4762031 | 0.81 | CRHR1 (0.43) | CRHR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4767150 | 0.79 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4762057 | 0.79 | CRHR1 (0.42) | CRHR1SRD5A1GPR119 | |
| SCHEMBL2190889 | 0.78 | CRHR1 (0.54) | CRHR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4766861 | 0.77 | GPR119 (0.38) | CRHR1CYP1A2CYP2C19GPR119TRPV1 | |
| SCHEMBL4804115 | 0.74 | CRHR1 (0.41) | CRHR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4762104 | 0.74 | CRHR1 (0.43) | CRHR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL27624988 | 0.74 | CRHR1 (0.52) | CRHR1HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462622-B2 | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists | GLAXO GROUP LIMITED (GB) | 2008-12-09 | — | — | US | claimed |
| EP-1395591-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-06-04 | — | — | EP | claimed |
| US-7462622-B2 | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists | GLAXO GROUP LIMITED (GB) | 2008-12-09 | — | — | US | disclosed |
| EP-1395591-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-06-04 | — | — | EP | disclosed |
| US-20050054661-A1 | Corticotropin releasing factor antagonists | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054661-A1 | Corticotropin releasing factor antagonists | CRHR1, CRH, CRHR2 | CRHR1 1/4885HTR1A 288/4885DRD2 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.