Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792853 | 0.88 | CDK9 (0.38) | HDAC1HDAC8IDO1PPARGSMN1; SMN2 | |
| SCHEMBL4793844 | 0.83 | HRH3 (0.39) | HDAC1HDAC8IDO1PPARGSMN1; SMN2 | |
| SCHEMBL4762113 | 0.78 | CDK9 (0.43) | IDO1SMN1; SMN2ALDH1A1LMNACYP11B1 | |
| SCHEMBL4791558 | 0.70 | HRH3 (0.37) | HDAC1SMN1; SMN2ALDH1A1LMNACYP11B1 | |
| SCHEMBL15345067 | 0.69 | CYP11B1 (0.68) | SMN1; SMN2ALDH1A1LMNACYP11B1CYP11B2 | |
| SCHEMBL2878971 | 0.67 | HRH3 (0.58) | F2HRH3 | |
| SCHEMBL2881787 | 0.65 | BRD4 (0.60) | HDAC1IDO1PPARGSMN1; SMN2ALDH1A1 | |
| SCHEMBL14376776 | 0.65 | HDAC6 (0.70) | HDAC1HDAC8IDO1PPARGSMN1; SMN2 | |
| SCHEMBL4155158 | 0.65 | HPGD (0.43) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL13559830 | 0.65 | CYP11B1 (0.71) | SMN1; SMN2ALDH1A1LMNACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | claimed |
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |