Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762035 | 0.88 | HDAC1 (0.39) | CDK9HDAC1HDAC8SMN1; SMN2ALDH1A1 | |
| SCHEMBL4793844 | 0.87 | HRH3 (0.39) | CDK9HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL4762113 | 0.81 | CDK9 (0.43) | CDK9SMN1; SMN2ALDH1A1LMNACYP11B1 | |
| SCHEMBL4791558 | 0.71 | HRH3 (0.37) | CDK9HDAC1HDAC6SMN1; SMN2ALDH1A1 | |
| SCHEMBL4175289 | 0.70 | HRH3 (0.46) | HTTHRH3 | |
| SCHEMBL14376776 | 0.68 | HDAC6 (0.70) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL2881787 | 0.68 | BRD4 (0.60) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4155158 | 0.68 | HPGD (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13559830 | 0.68 | CYP11B1 (0.71) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL13085854 | 0.67 | HRH3 (0.59) | SMN1; SMN2RAB9ALMNACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | claimed |