Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494233 | 0.79 | CNR1 (0.40) | NR1I2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL4762926 | 0.79 | TP53 (0.38) | NR1I2ALDH1A1CNR1TSHRMAPT | |
| SCHEMBL1494186 | 0.77 | NR1I2 (0.43) | NR1I2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL1494399 | 0.76 | NR1I2 (0.41) | NR1I2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL1494181 | 0.75 | HPGDS (0.40) | NR1I2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL12101215 | 0.73 | PAX8 (0.40) | NR1I2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL3411434 | 0.72 | ACHE (0.47) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL1494481 | 0.71 | CNR1 (0.57) | CNR1MAPTHTR6 | |
| SCHEMBL12101208 | 0.70 | CNR1 (0.38) | NR1I2ALDH1A1CNR1MEN1KMT2A | |
| SCHEMBL1494496 | 0.70 | NR1I2 (0.37) | NR1I2ALDH1A1CNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924264-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025925-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| EP-1725540-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005095359-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-13 | — | — | WO | disclosed |