Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916401 | 0.81 | HTR1A (0.37) | SLC22A6MEN1KMT2AKDM4ELMNA | |
| SCHEMBL3067702 | 0.80 | GUSB (0.36) | L3MBTL1 | |
| SCHEMBL27926133 | 0.80 | NR4A2 (0.51) | SMN1; SMN2LMNAL3MBTL1TSHRPMP22 | |
| Citric Acid SCHEMBL27926134 | 0.80 | ADAM17 (0.56) | MEN1KMT2AKDM4ELMNAPOLB | |
| SCHEMBL28231180 | 0.80 | SLC22A6 (0.63) | SLC22A6SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL31181908 | 0.80 | SLC22A6 (0.59) | SLC22A6SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL9184658 | 0.79 | MAPT (0.57) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6835665 | 0.77 | SLC22A6 (0.68) | SLC22A6SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL1714417 | 0.77 | SLC22A6 (0.68) | SLC22A6SMN1; SMN2MAPTMEN1KMT2A | |
| Dl-Tryptophan SCHEMBL9184636 | 0.77 | KMT2A (0.76) | SMN1; SMN2MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106414376-A | Process for obtaining optically active pirlindole enantiomers and salts thereof | 特克尼梅德医疗技术股份公司 | 2017-02-15 | — | — | CN | claimed |
| CN-1922189-B | Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor | GRUENENTHAL GMBH | 2010-06-16 | — | — | CN | claimed |
| CN-101693714-A | spirocyclic cyclohexane derivatives | GRUENENTHAL CHEMIE | 2010-04-14 | — | — | CN | claimed |
| CN-100577664-C | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2010-01-06 | — | — | CN | claimed |
| EP-1778680-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2008-10-08 | — | — | EP | claimed |
| CN-1922189-A | Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor | GRUENENTHAL GMBH (DE) | 2007-02-28 | — | — | CN | claimed |
| CN-1735619-A | spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2006-02-15 | — | — | CN | claimed |
| CN-1662538-A | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN PHARMACEUTICALS LTD (IN) | 2005-08-31 | — | — | CN | claimed |
| CN-107949557-B | 2-aryl-and 2-aralkyl-benzimidazoles as mIDH1 inhibitors | 德国癌症研究公共权益基金会 | 2021-11-02 | — | — | CN | disclosed |
| CN-101693714-B | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2013-05-29 | — | — | CN | disclosed |
| CN-1922189-B | Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor | GRUENENTHAL GMBH | 2010-06-16 | — | — | CN | disclosed |
| CN-101693714-A | spirocyclic cyclohexane derivatives | GRUENENTHAL CHEMIE | 2010-04-14 | — | — | CN | disclosed |
| CN-100577664-C | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2010-01-06 | — | — | CN | disclosed |
| CN-1922189-A | Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor | GRUENENTHAL GMBH (DE) | 2007-02-28 | — | — | CN | disclosed |
| CN-1735619-A | spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2006-02-15 | — | — | CN | disclosed |
| CN-1662538-A | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN PHARMACEUTICALS LTD (IN) | 2005-08-31 | — | — | CN | disclosed |