Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763400 | 0.80 | SLC22A6 (0.52) | L3MBTL1 | |
| SCHEMBL27602917 | 0.77 | SLC6A4 (0.43) | GUSBL3MBTL1SLC6A4NR3C1NR3C2 | |
| SCHEMBL7364794 | 0.75 | SLC22A6 (0.57) | GUSBL3MBTL1SLC6A4IDO1HTR6 | |
| SCHEMBL8916401 | 0.75 | HTR1A (0.37) | L3MBTL1HTR6 | |
| SCHEMBL27623627 | 0.74 | L3MBTL1 (0.45) | GUSBL3MBTL1SLC6A4IDO1HTR6 | |
| SCHEMBL27713315 | 0.74 | SLC6A4 (0.44) | GUSBL3MBTL1SLC6A4NR3C1NR3C2 | |
| Citric Acid SCHEMBL3067698 | 0.73 | IMPDH2 (0.61) | L3MBTL1SLC6A4 | |
| SCHEMBL4485828 | 0.68 | TSHR (0.64) | SLC6A4DRD2DRD4DRD3CDK2 | |
| SCHEMBL1434181 | 0.67 | F7 (0.58) | SLC6A4IDO1CDK2HTR6 | |
| SCHEMBL24328924 | 0.67 | SMN1; SMN2 (0.60) | SLC6A4NR3C1NR3C2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101772497-A | New crystalline forms of 2 -hydroxy- 3- [5- (morpholin- 4- ylmethyl) pyridin-2-yl] ih- indole- 5 -carbonitrile citrate | ASTRAZENECA AB | 2010-07-07 | — | — | CN | claimed |
| US-20100267720-A1 | Crystalline Forms of 2-Hydroxy-3- [5- (Morpholin- 4- Ylmethyl) Pyridin-2-YL] IH- Indole- 5 -Carbonitrile Citrate | ASTRAZENECA AB (SE) | 2010-10-21 | — | — | US | disclosed |
| CN-101772497-A | New crystalline forms of 2 -hydroxy- 3- [5- (morpholin- 4- ylmethyl) pyridin-2-yl] ih- indole- 5 -carbonitrile citrate | ASTRAZENECA AB | 2010-07-07 | — | — | CN | disclosed |
| CN-101772497-A | New crystalline forms of 2 -hydroxy- 3- [5- (morpholin- 4- ylmethyl) pyridin-2-yl] ih- indole- 5 -carbonitrile citrate | ASTRAZENECA AB | 2010-07-07 | — | — | CN | disclosed |
| CN-101679353-A | A new process for the manufacturing of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1h-indole-5-carbonitrile 701 | ASTRAZENECA AB | 2010-03-24 | — | — | CN | disclosed |
| WO-2007089193-A1 | A PROCESS FOR PREPARING 2-HYDROXY-3- [5- (MORPHOLIN-4-YLMETHYL)PYRIDIN-2-YL] LH-INDOLE-5-CARBONITRILE AS A FREE BASE OR SALTS THEREOF | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | WO | disclosed |