Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
| ▸ | KDM6B | O15054 | 6/20 | 0.48 |
| ▸ | KDM4A | O75164 | 6/20 | 0.48 |
| ▸ | HIF1AN | Q9NWT6 | 6/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.48 |
| ▸ | KDM4D | Q6B0I6 | 5/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM3B | Q7LBC6 | 5/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27810931 | 0.82 | KMT2A (0.48) | MAPTKDM6BKDM4AHIF1ANKDM2A | |
| SCHEMBL6297322 | 0.80 | MAPT (0.54) | MAPTKDM6BKDM4AHIF1ANKDM2A | |
| SCHEMBL10324192 | 0.72 | TNKS (0.43) | HTR3AHRH4ALDH1A1GLATSHR | |
| SCHEMBL10322954 | 0.72 | HTR3A (0.46) | HTR3AHRH4ALDH1A1PKML3MBTL1 | |
| SCHEMBL32671634 | 0.72 | POLB (0.58) | MAPTHTR3AHRH4ALDH1A1TSHR | |
| SCHEMBL27737544 | 0.69 | NSD2 (0.42) | HRH4ALDH1A1PKML3MBTL1KMT2A | |
| SCHEMBL21477245 | 0.69 | ALDH1A1 (0.52) | MAPTHTR3AHRH4ALDH1A1GLA | |
| SCHEMBL23900414 | 0.69 | KDM6B (0.61) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL10322786 | 0.68 | KDM4E (0.45) | MAPTHTR3AHRH4ALDH1A1PKM | |
| SCHEMBL7712513 | 0.67 | HRH4 (0.49) | HTR3AHRH4ALDH1A1GLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | disclosed |
| US-6878704-B2 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-04-12 | — | — | US | disclosed |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | MLN, MSH2, MRPL21 | MAPT 3122/4885HTR3A 4448/4885KDM6B 4440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.