Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059312 | 0.83 | NR2E1 (0.50) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 | |
| SCHEMBL31078247 | 0.81 | KDM4E (0.64) | NR2E1SLC2A1HSD17B10KDM4ECYP1A2 | |
| SCHEMBL4727252 | 0.81 | KDM4E (0.64) | NR2E1SLC2A1HSD17B10KDM4ECYP1A2 | |
| SCHEMBL31078488 | 0.81 | NR2E1 (0.64) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 | |
| SCHEMBL31078875 | 0.81 | NR2E1 (0.60) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 | |
| SCHEMBL12660565 | 0.81 | NR2E1 (0.60) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 | |
| SCHEMBL4903024 | 0.81 | NR2E1 (0.64) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 | |
| SCHEMBL2309545 | 0.81 | NR2E1 (0.60) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 | |
| SCHEMBL4725539 | 0.80 | KMT2A (0.49) | NR2E1SLC2A1HSD17B10KDM4ECYP1A2 | |
| SCHEMBL4728062 | 0.80 | KDM4E (0.63) | NR2E1HSD17B10KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |