Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764196 | 1.00 | RIPK1 (0.49) | RIPK1UCHL1USP30LMNANPSR1 | |
| SCHEMBL2545927 | 0.81 | RIPK1 (0.46) | RIPK1UCHL1USP30GPR119 | |
| SCHEMBL4791424 | 0.81 | TSHR (0.43) | UCHL1USP30LMNANPSR1TSHR | |
| SCHEMBL4791421 | 0.81 | TSHR (0.43) | UCHL1USP30LMNANPSR1TSHR | |
| SCHEMBL17067869 | 0.79 | RIPK1 (0.73) | RIPK1UCHL1LMNANPSR1TSHR | |
| SCHEMBL469686 | 0.79 | RIPK1 (0.73) | RIPK1UCHL1LMNANPSR1TSHR | |
| SCHEMBL17067870 | 0.79 | RIPK1 (0.73) | RIPK1UCHL1LMNANPSR1TSHR | |
| SCHEMBL4764260 | 0.78 | CYP3A4 (0.43) | USP30LMNANPSR1TSHRMAPT | |
| SCHEMBL4762740 | 0.77 | ALDH1A1 (0.42) | UCHL1USP30LMNANPSR1TSHR | |
| SCHEMBL4762739 | 0.77 | ALDH1A1 (0.42) | UCHL1USP30LMNANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881975-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006121218-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-11-16 | — | — | WO | disclosed |