Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 9/20 | 0.37 |
| ▸ | HTR2A | P28223 | 9/20 | 0.37 |
| ▸ | DRD3 | P35462 | 8/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764410 | 0.95 | MAP3K14 (0.38) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| SCHEMBL4768990 | 0.83 | CSNK2A2 (0.38) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| SCHEMBL14102730 | 0.82 | CSNK2A2 (0.40) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| Oxalic Acid SCHEMBL4768421 | 0.82 | CSNK2A2 (0.43) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| SCHEMBL4773708 | 0.81 | SMN1; SMN2 (0.39) | CSNK2A2CSNK2BCSNK2A1HTR2ASMN1; SMN2 | |
| Oxalic Acid SCHEMBL4770325 | 0.81 | CSNK2A2 (0.43) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| SCHEMBL4772558 | 0.80 | CSNK2A2 (0.45) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| SCHEMBL4073036 | 0.80 | CSNK2A2 (0.39) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| Pyridine SCHEMBL4769403 | 0.80 | SMN1; SMN2 (0.40) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A | |
| SCHEMBL4763741 | 0.80 | CSNK2A2 (0.43) | CSNK2A2CSNK2BCSNK2A1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020445-B1 | FUSED PYRIDINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-6875761-B2 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. | 2004-10-14 | — | — | US | disclosed |
| US-6790844-B2 | MUSCLE RELAXANTS; ANTISEROTONINE AGENT | EISAI CO., LTD (JP) | 2004-09-14 | — | — | US | disclosed |
| US-20020013460-A1 | Condensed pyridine compound | EISAI CO., LTD | 2002-01-31 | — | — | US | disclosed |
| US-6340759-B1 | ANTISPASMODIC AGENTS | EISAI CO., LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1020445-A1 | FUSED PYRIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013460-A1 | Condensed pyridine compound | MUSK, HTR1A, PAX3 | CSNK2A2 887/4885CSNK2B 862/4885CSNK2A1 661/4885 |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | MUSK, HTR1A, RYR1 | CSNK2A2 2189/4885CSNK2B 1865/4885CSNK2A1 1779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.