Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 5/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSH | P09668 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.34 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.34 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076730 | 0.92 | MAPT (0.65) | MAPTOPRK1KMT2ACOMTCTSB | |
| SCHEMBL1029385 | 0.87 | KMT2A (0.59) | MAPTOPRK1KMT2ACOMTCTSB | |
| SCHEMBL7944048 | 0.83 | MAPT (0.67) | MAPTOPRK1KMT2ACOMTKDM4E | |
| SCHEMBL4764607 | 0.82 | KDM4E (0.41) | MAPTOPRK1KMT2ACOMTCTSB | |
| SCHEMBL11316137 | 0.77 | COMT (0.76) | OPRK1KMT2ACOMTKDM4EHTT | |
| SCHEMBL27638396 | 0.77 | OPRK1 (0.57) | MAPTOPRK1KMT2ACOMTCTSB | |
| SCHEMBL7690466 | 0.74 | MAPT (0.67) | MAPTOPRK1KMT2ACOMTKDM4E | |
| SCHEMBL7687038 | 0.73 | MAPT (0.65) | MAPTOPRK1KMT2ACOMTKDM4E | |
| Chlorquinaldol SCHEMBL29641617 | 0.73 | MAPT (1.00) | MAPTOPRK1KMT2AKDM4EHTT | |
| Chlorquinaldol SCHEMBL29607534 | 0.73 | MAPT (1.00) | MAPTOPRK1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904482-A2 | INDOLYLMALEIMIDE DERIVATIVES | Novartis AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006533-A2 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | disclosed |