Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSH | P09668 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764600 | 0.82 | MAPT (0.56) | KDM4EHTTPKMKMT2AOPRK1 | |
| SCHEMBL1029385 | 0.79 | KMT2A (0.59) | KDM4EKMT2AOPRK1ALDH1A1MEN1 | |
| SCHEMBL1076730 | 0.77 | MAPT (0.65) | KDM4EHTTPKMKMT2AOPRK1 | |
| SCHEMBL7944048 | 0.73 | MAPT (0.67) | KDM4EHTTPKMKMT2AOPRK1 | |
| SCHEMBL27638396 | 0.72 | OPRK1 (0.57) | KDM4EKMT2AOPRK1ALDH1A1MAPT | |
| SCHEMBL11316137 | 0.70 | COMT (0.76) | KDM4EHTTKMT2AOPRK1ALDH1A1 | |
| SCHEMBL4293438 | 0.69 | KMT2A (0.65) | KDM4EHTTPKMKMT2AOPRK1 | |
| SCHEMBL21034060 | 0.68 | KDM4E (0.56) | KDM4EHTTPKMKMT2AGAA | |
| SCHEMBL30961312 | 0.68 | OPRK1 (0.54) | KDM4EHTTKMT2AOPRK1ALDH1A1 | |
| SCHEMBL7692195 | 0.67 | KMT2A (0.67) | KDM4EHTTPKMKMT2AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904482-A2 | INDOLYLMALEIMIDE DERIVATIVES | Novartis AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006533-A2 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | disclosed |