Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.39 |
| ▸ | FABP1 | P07148 | 5/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27729510 | 0.81 | PTGS1 (0.40) | ALDH1A1NR1H4FABP1HSD17B13NPSR1 | |
| SCHEMBL23906961 | 0.81 | NOTUM (0.45) | ALDH1A1NR1H4FABP1HSD17B13HIF1A | |
| SCHEMBL26870513 | 0.81 | GABRA5 (0.40) | ALDH1A1NR1H4FABP1HSD17B13NPSR1 | |
| SCHEMBL27732988 | 0.80 | FFAR4 (0.39) | NR1H4FABP1HSD17B13FFAR4GABRA5 | |
| SCHEMBL22789944 | 0.80 | NR1H4 (0.53) | NR1H4FABP1HSD17B13FABP4 | |
| SCHEMBL4723502 | 0.79 | ALDH1A1 (0.56) | ALDH1A1NPSR1GABRA5MEN1KMT2A | |
| SCHEMBL22790072 | 0.78 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL22789989 | 0.76 | NR1H4 (0.59) | NR1H4HSD17B13 | |
| SCHEMBL22790026 | 0.74 | PPARG (0.45) | ALDH1A1NR1H4FABP1HSD17B13MEN1 | |
| SCHEMBL4974872 | 0.74 | PTGS2 (0.58) | ALDH1A1NPSR1FFAR4GABRA5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979350-A1 | ARYL-ISOXAZOL-4-YL-IMIDAZO[1,2-A]PYRIDINE USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE VIA GABA RECEPTORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007082806-A1 | ARYL-ISOXAZOL-4-YL-IMIDAZO[1,2-A]PYRIDINE USEFUL FOR THE TREATMENT OF ALZHEIMER’S DISEASE VIA GABA RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |