Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417334 | 0.86 | GPR119 (0.59) | GPR119SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL31420782 | 0.84 | CKS1B (0.55) | GPR119KDM4EHPGDCKS1BSKP1 | |
| SCHEMBL4420158 | 0.83 | GPR119 (0.54) | GPR119SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL805498 | 0.82 | SIRT2 (0.52) | SIRT2SIRT1SIRT3CHRM4CKS1B | |
| SCHEMBL4703208 | 0.81 | CHRM4 (0.56) | GPR119SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL13934842 | 0.81 | DKK1 (0.67) | SIRT2SIRT1SIRT3CHRM4CKS1B | |
| SCHEMBL4954279 | 0.80 | GPR119 (0.61) | GPR119KDM4ECKS1BSKP1SKP2 | |
| SCHEMBL15383665 | 0.80 | KDM4E (0.61) | GPR119KDM4EALDH1A1GAATSHR | |
| SCHEMBL23107653 | 0.78 | SIRT2 (0.53) | SIRT2SIRT1SIRT3CKS1BSKP1 | |
| SCHEMBL572043 | 0.78 | SIGMAR1 (0.59) | GPR119KDM4EALDH1A1CYP2C19DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |