Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PARG | Q86W56 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771497 | 0.88 | ADORA2B (0.43) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4765716 | 0.88 | ADORA2A (0.43) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4763154 | 0.86 | BTK (0.40) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4762252 | 0.86 | ADORA2B (0.43) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4771107 | 0.81 | ADORA2B (0.49) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4766303 | 0.80 | ADORA2B (0.36) | ADORA2AADORA2BADORA3ADORA1BRD4 | |
| SCHEMBL4762597 | 0.79 | ADORA2B (0.51) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL4764038 | 0.77 | ADORA2B (0.44) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4771398 | 0.77 | ADORA2A (0.38) | ADORA2AADORA2BCREBBPADORA3ADORA1 | |
| SCHEMBL4859850 | 0.74 | DCTPP1 (0.41) | CREBBPBRD4PFKFB3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-7449473-B2 | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as A2b adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20050119287-A1 | A2B adenosine receptor antagonists | GILEAD PALO ALTO, INC. | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119287-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA3 | ADORA2A 2/4885ADORA2B 1/4885CREBBP 2825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.