Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 6/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767762 | 0.89 | AQP1 (0.51) | AQP1PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4595617 | 0.86 | AQP1 (0.66) | AQP1PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4713102 | 0.85 | AQP1 (0.54) | AQP1PARP1CNR1CNR2BRD4 | |
| SCHEMBL4712234 | 0.85 | AQP1 (0.67) | AQP1PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4710394 | 0.84 | CNR1 (0.38) | AQP1PARP1CNR1CNR2BRD4 | |
| SCHEMBL4762568 | 0.84 | PARP1 (0.48) | AQP1PARP1BRD4CREBBPHTR1A | |
| SCHEMBL4765139 | 0.83 | AQP1 (0.49) | AQP1PARP1CNR1HTR1AHTR7 | |
| SCHEMBL4596891 | 0.83 | THRB (0.39) | AQP1CNR1CNR2BRD4CREBBP | |
| SCHEMBL5583714 | 0.82 | CNR1 (0.39) | AQP1PARP1CNR1CNR2BRD4 | |
| SCHEMBL4596604 | 0.81 | PARP1 (0.45) | AQP1PARP1CREBBPHTR7GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |