Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765146 | 0.89 | AQP1 (0.50) | AQP1PARP1HTR1ABRD4CREBBP | |
| SCHEMBL4595617 | 0.86 | AQP1 (0.66) | AQP1PARP1HTR1ABRD4CREBBP | |
| SCHEMBL4713784 | 0.86 | HTR1A (0.42) | AQP1PARP1HTR1ABRD4CREBBP | |
| SCHEMBL4767758 | 0.84 | AQP1 (0.48) | AQP1ALOX15P2RX7 | |
| SCHEMBL4714782 | 0.84 | MET (0.42) | AQP1PARP1HTR1ABRD4CREBBP | |
| SCHEMBL4595103 | 0.82 | NUDT1 (0.43) | AQP1PARP1HTR1ABRD4CREBBP | |
| SCHEMBL5185008 | 0.81 | AQP1 (0.57) | AQP1ALOX15P2RX7 | |
| SCHEMBL4219883 | 0.81 | AQP1 (0.69) | AQP1P2RX7 | |
| SCHEMBL4713102 | 0.80 | AQP1 (0.54) | AQP1PARP1HTR1ABRD4CREBBP | |
| SCHEMBL4712234 | 0.80 | AQP1 (0.67) | AQP1PARP1HTR1ABRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879569-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | Wyeth (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006116221-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | WYETH (US) | 2006-11-02 | — | — | WO | claimed |
| EP-1898895-A2 | TREATMENT OF DRUG ABUSE | Wyeth (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116148-A2 | (7-ARLYSUBSTITUTED 2, 3-DIHYDR0-1-BENZ0FURAN-2-YL) ALKYLAMINES IN THE TREATMENT' OF SUBSTANCE ABUSE | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |