Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 12/20 | 0.56 |
| ▸ | KDM4A | O75164 | 12/20 | 0.56 |
| ▸ | HIF1AN | Q9NWT6 | 12/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 12/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 11/20 | 0.56 |
| ▸ | KDM3B | Q7LBC6 | 11/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 10/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763775 | 0.78 | KDM6B (0.44) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL23900414 | 0.76 | KDM6B (0.61) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL15330591 | 0.73 | ALDH1A1 (0.39) | HPGDKDM4EALDH1A1 | |
| SCHEMBL15349327 | 0.72 | KDM6B (0.56) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL4766387 | 0.71 | KDM6B (1.00) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL2219244 | 0.71 | KDM6B (0.60) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL13295349 | 0.71 | KDM6B (0.56) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL10787908 | 0.70 | NPC1 (0.47) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL10561964 | 0.68 | KDM6B (0.74) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL23900635 | 0.68 | KDM6B (0.51) | KDM6BKDM4AHIF1ANKDM2AKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | disclosed |
| US-6878704-B2 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-04-12 | — | — | US | disclosed |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-25 | — | — | US | disclosed |
| US-20040023806-A1 | N-phenylcarbamates having a microbicide insecticide and acaricide effect | BAYER AKTIENGESELLSCHAFT (DE) | 2004-02-05 | — | — | US | disclosed |
| EP-1309565-A1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012199-A1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023806-A1 | N-phenylcarbamates having a microbicide insecticide and acaricide effect | CBR3, CBR1, CYP1B1 | KDM6B 1421/4885KDM4A 1500/4885HIF1AN 1750/4885 |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | MLN, MSH2, MRPL21 | KDM6B 4440/4885KDM4A 3952/4885HIF1AN 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.