Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.64 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.64 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | METAP2 | P50579 | 1/20 | 0.59 |
| ▸ | NSD2 | O96028 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31680569 | 0.84 | KMT2A (0.89) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11901003 | 0.84 | KMT2A (0.89) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL4744541 | 0.79 | TSHR (0.43) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1032002 | 0.79 | MAPK1 (0.77) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8635709 | 0.79 | KMT2A (1.00) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1984940 | 0.79 | KMT2A (1.00) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL791333 | 0.78 | GAA (0.57) | GAAL3MBTL1KDM4E | |
| SCHEMBL29469069 | 0.78 | GAA (0.57) | GAAL3MBTL1KDM4E | |
| SCHEMBL7828799 | 0.78 | KMT2A (0.77) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1979028 | 0.77 | KMT2A (0.71) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979353-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007084667-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI PHARMACEUTICAL, INC. (US) | 2007-07-26 | — | — | WO | disclosed |