Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29665196 | 0.84 | BCHE (0.53) | BCHEGAAALDH1A1KMT2AHPGD | |
| SCHEMBL1696921 | 0.79 | LMNA (0.50) | BCHENPC1KMT2AHPGDLMNA | |
| SCHEMBL19347408 | 0.79 | SPHK2 (0.37) | NPC1TRPV1GAAALDH1A1KMT2A | |
| SCHEMBL3954847 | 0.78 | CTSS (0.46) | — | |
| SCHEMBL19347406 | 0.76 | HTT (0.39) | TRPV1GAAHPGDCA12CA1 | |
| SCHEMBL791334 | 0.75 | ALDH1A1 (0.42) | BCHEGAAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL1720194 | 0.74 | ALDH1A1 (0.67) | BCHENPC1GAAALDH1A1KMT2A | |
| SCHEMBL8621389 | 0.74 | GAA (0.55) | BCHEGAAALDH1A1KMT2AHPGD | |
| SCHEMBL5785644 | 0.74 | SMN1; SMN2 (0.49) | BCHENPC1GAAALDH1A1KMT2A | |
| SCHEMBL2095021 | 0.73 | GAA (0.53) | BCHEGAAALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979353-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007084667-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI PHARMACEUTICAL, INC. (US) | 2007-07-26 | — | — | WO | disclosed |