Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | MYC | P01106 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765812 | 1.00 | P2RX7 (0.38) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4724504 | 0.90 | ITGB2 (0.38) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4724501 | 0.90 | ITGB2 (0.38) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4718873 | 0.85 | P2RX7 (0.35) | P2RX7RORCPDE3BPDE3AHSD11B1 | |
| SCHEMBL4718877 | 0.85 | P2RX7 (0.35) | P2RX7RORCPDE3BPDE3AHSD11B1 | |
| SCHEMBL4722935 | 0.84 | P2RX7 (0.40) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4722940 | 0.84 | P2RX7 (0.40) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4723491 | 0.84 | P2RX7 (0.36) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4723495 | 0.84 | P2RX7 (0.36) | P2RX7RORCPDE3BPDE3ANOTUM | |
| SCHEMBL4722458 | 0.83 | ABL1 (0.39) | P2RX7RORCPDE3BPDE3ASOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |