Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775234 | 0.96 | LMNA (0.49) | LMNAPKMHTTNPC1RAB9A | |
| SCHEMBL4766014 | 0.85 | ADORA1 (0.47) | LMNAPKMHTTNPC1RAB9A | |
| SCHEMBL4768829 | 0.84 | KDM4E (0.44) | LMNAPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4769061 | 0.84 | ADORA2A (0.43) | LMNAPKMHTTNPC1RAB9A | |
| SCHEMBL4771450 | 0.82 | NPC1 (0.52) | LMNAPKMHTTNPC1RAB9A | |
| SCHEMBL4775920 | 0.81 | ADORA1 (0.54) | LMNANPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL4771758 | 0.81 | ADORA1 (0.43) | PKMHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4773065 | 0.80 | ADORA1 (0.43) | PKMNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4769102 | 0.80 | KMT2A (0.55) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4770635 | 0.79 | CYP1A2 (0.52) | SMN1; SMN2TSHRALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878733-A1 | Pyrimidine derivatives as ALK-5 inhibitors | Novartis AG (CH) | 2008-01-16 | — | — | EP | disclosed |