Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767273 | 1.00 | ADORA2A (0.35) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4771562 | 0.93 | ADORA2A (0.39) | ADORA2AADORA2BADORA1ALDH1A1HDAC2 | |
| SCHEMBL4771574 | 0.93 | ADORA2A (0.39) | ADORA2AADORA2BADORA1ALDH1A1HDAC2 | |
| SCHEMBL4762591 | 0.91 | MAPT (0.37) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4762596 | 0.91 | MAPT (0.37) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4764053 | 0.90 | ALDH1A1 (0.41) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4765667 | 0.89 | ADORA2A (0.40) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4767816 | 0.88 | MAPT (0.42) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4767823 | 0.88 | MAPT (0.42) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4769234 | 0.87 | NPBWR1 (0.41) | ADORA2AADORA2BADORA1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |