Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.55 |
| ▸ | APOB | P04114 | 2/20 | 0.52 |
| ▸ | MTTP | P55157 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4765546 | 0.94 | MEN1 (0.53) | MEN1KMT2AATMCREBBPAPOB | |
| SCHEMBL4768623 | 0.85 | RAB9A (0.58) | CREBBPTP53NPC1HTTRAB9A | |
| SCHEMBL4770555 | 0.85 | NPC1 (0.51) | MEN1KMT2AATMTP53NPC1 | |
| SCHEMBL4768583 | 0.83 | TMPRSS2 (0.62) | MEN1KMT2AATMTP53NPC1 | |
| SCHEMBL4777053 | 0.82 | HRH3 (0.57) | MEN1KMT2AATMTP53NPC1 | |
| SCHEMBL4765318 | 0.82 | MEN1 (0.56) | MEN1KMT2AATMTP53NPC1 | |
| SCHEMBL4768212 | 0.82 | NPC1 (0.58) | MEN1KMT2AATMTP53NPC1 | |
| SCHEMBL4772451 | 0.82 | TP53 (0.53) | MEN1KMT2AATMTP53NPC1 | |
| SCHEMBL8208363 | 0.81 | MTTP (0.57) | APOBMTTPSMN1; SMN2MAPTSMO | |
| SCHEMBL4770439 | 0.81 | HRH3 (0.52) | MEN1KMT2ATP53NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |