Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.36 |
| ▸ | JUN | P05412 | 5/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.36 |
| ▸ | RELA | Q04206 | 5/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | XPO1 | O14980 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ATF1 | P18846 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772216 | 0.87 | STK17B (0.40) | STK17BSTK17APOLBAPEX1NFKB1 | |
| SCHEMBL4774497 | 0.85 | NFKB1 (0.40) | STK17BSTK17APOLBAPEX1NFKB1 | |
| SCHEMBL4773876 | 0.82 | NFKB1 (0.40) | STK17BSTK17APOLBAPEX1NFKB1 | |
| SCHEMBL4772853 | 0.82 | TRPA1 (0.41) | STK17BSTK17AJAK3POLBAPEX1 | |
| SCHEMBL4765932 | 0.82 | STK17B (0.43) | STK17BSTK17APOLBAPEX1NFKB1 | |
| SCHEMBL22261317 | 0.81 | JAK3 (0.54) | STK17BSTK17AJAK3SYKPLAU | |
| SCHEMBL29622837 | 0.81 | JAK3 (0.54) | STK17BSTK17AJAK3SYKPLAU | |
| SCHEMBL4765257 | 0.81 | STK17B (0.47) | STK17BSTK17AJAK3NFKB1JUN | |
| SCHEMBL4768852 | 0.81 | ALDH1A1 (0.46) | STK17BSTK17AJAK3POLBAPEX1 | |
| SCHEMBL4768060 | 0.81 | LRRK2 (0.46) | STK17BSTK17APOLBAPEX1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |