Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4768268 | 0.94 | SLC2A1 (0.47) | MAOAMAOBNPC1RAB9AMAPT | |
| SCHEMBL4768483 | 0.93 | ALDH1A1 (0.51) | MAOAMAOBNPC1RAB9AMAPT | |
| Trifluoroacetic Acid SCHEMBL4772660 | 0.87 | ESR1 (0.50) | NPC1RAB9AMAPTHRH3CHRNA7 | |
| SCHEMBL4774628 | 0.83 | TMPRSS2 (0.61) | NPC1RAB9AMAPTHRH3PLAU | |
| SCHEMBL1789555 | 0.82 | CCR3 (0.49) | MAPTHRH3CHRNA7ROCK2CHRM2 | |
| SCHEMBL4768264 | 0.81 | HRH3 (0.50) | NPC1RAB9AMAPTHRH3MELK | |
| SCHEMBL4770147 | 0.81 | HRH3 (0.46) | NPC1RAB9AMAPTHRH3PLAU | |
| SCHEMBL4765111 | 0.80 | HRH3 (0.46) | NPC1RAB9AMAPTHRH3MELK | |
| SCHEMBL4768500 | 0.80 | HRH3 (0.57) | NPC1RAB9AHRH3PLAUTMPRSS2 | |
| SCHEMBL4768058 | 0.80 | NPC1 (0.69) | NPC1RAB9AMAPTHRH3MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |