Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.61 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.51 |
| ▸ | RELA | Q04206 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4767916 | 0.93 | TMPRSS2 (0.55) | TMPRSS2PLAURAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4768500 | 0.88 | HRH3 (0.57) | TMPRSS2PLAURAB9ANPC1HRH3 | |
| SCHEMBL4768623 | 0.86 | RAB9A (0.58) | TMPRSS2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1787983 | 0.85 | HRH3 (0.55) | TMPRSS2RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4774646 | 0.85 | HRH3 (0.67) | RAB9ANPC1SMN1; SMN2HRH3NFKB1 | |
| SCHEMBL4793943 | 0.85 | ABCB1 (0.55) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4768483 | 0.84 | ALDH1A1 (0.51) | TMPRSS2PLAURAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4770633 | 0.83 | HRH3 (0.64) | TMPRSS2RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4768412 | 0.83 | MAOA (0.53) | TMPRSS2PLAURAB9ANPC1MAPT | |
| SCHEMBL4765225 | 0.83 | HRH3 (0.55) | TMPRSS2RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |