Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4770823 | 0.94 | SLC2A1 (0.47) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6294868 | 0.84 | ROCK2 (0.55) | POLBROCK2 | |
| SCHEMBL4765111 | 0.83 | HRH3 (0.46) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4765905 | 0.81 | NPC1 (0.69) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4768412 | 0.81 | MAOA (0.53) | HRH3RAB9ANPC1MAPTTMPRSS2 | |
| SCHEMBL4770201 | 0.81 | SMN1; SMN2 (0.50) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4768483 | 0.80 | ALDH1A1 (0.51) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4772409 | 0.80 | RAB9A (0.51) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4774583 | 0.79 | HRH3 (0.57) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4774510 | 0.79 | RAB9A (0.57) | HRH3RAB9AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |