Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.58 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163018 | 0.81 | FASN (0.56) | OPRM1OPRD1OPRK1OPRL1KMT2A | |
| SCHEMBL5467320 | 0.80 | SMN1; SMN2 (0.55) | OPRM1OPRD1OPRK1OPRL1GAA | |
| SCHEMBL986690 | 0.79 | GPR119 (0.47) | OPRM1OPRD1OPRK1OPRL1CCR1 | |
| SCHEMBL14033468 | 0.79 | NOS2 (0.58) | OPRM1OPRD1OPRK1OPRL1CCR1 | |
| SCHEMBL1308581 | 0.78 | — | — | |
| SCHEMBL3639204 | 0.78 | GRM5 (0.57) | OPRM1OPRD1OPRK1OPRL1CCR1 | |
| SCHEMBL9876730 | 0.76 | KMT2A (0.52) | OPRM1OPRD1OPRK1OPRL1GAA | |
| SCHEMBL9876733 | 0.76 | KMT2A (0.52) | OPRM1OPRD1OPRK1OPRL1GAA | |
| SCHEMBL2202814 | 0.76 | OPRM1 (0.56) | OPRM1OPRL1THRB | |
| SCHEMBL9876737 | 0.76 | KMT2A (0.52) | OPRM1OPRD1OPRK1OPRL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Vertex Pharmaceuticals Incorporated (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007111904-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-04 | — | — | WO | disclosed |