Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4765223 | 0.94 | MEN1 (0.44) | MEN1KMT2AMAPTUSP2PIN1 | |
| SCHEMBL4768583 | 0.82 | TMPRSS2 (0.62) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4770555 | 0.80 | NPC1 (0.51) | MEN1KMT2AMAPTUSP2SMN1; SMN2 | |
| SCHEMBL4772757 | 0.80 | HRH3 (0.52) | MEN1KMT2AMAPTMAOBSMN1; SMN2 | |
| SCHEMBL4774483 | 0.79 | SLC2A1 (0.52) | MEN1KMT2AMAPTPIN1SMN1; SMN2 | |
| SCHEMBL4767370 | 0.78 | MEN1 (0.58) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5823896 | 0.78 | HRH3 (0.54) | KMT2AMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4772451 | 0.78 | TP53 (0.53) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL4768212 | 0.78 | NPC1 (0.58) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4766059 | 0.77 | KDM4E (0.50) | MEN1KMT2AMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |