Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396113 | 0.84 | SIGMAR1 (0.55) | ALDH1A1SMN1; SMN2ALOX15SIGMAR1TDP1 | |
| SCHEMBL15834506 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2SIGMAR1TDP1KDM4E | |
| SCHEMBL18118428 | 0.81 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2SIGMAR1TDP1KDM4E | |
| SCHEMBL10223654 | 0.80 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2SIGMAR1TDP1KDM4E | |
| SCHEMBL11952855 | 0.79 | SIGMAR1 (0.54) | ALDH1A1SMN1; SMN2ALOX15SIGMAR1TDP1 | |
| SCHEMBL20668639 | 0.77 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2SIGMAR1TDP1TP53 | |
| SCHEMBL6897984 | 0.77 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2SIGMAR1TDP1TP53 | |
| SCHEMBL18997671 | 0.77 | SIGMAR1 (0.50) | ALDH1A1SMN1; SMN2SIGMAR1TDP1KDM4E | |
| SCHEMBL8616990 | 0.76 | SMN1; SMN2 (0.79) | ALDH1A1SMN1; SMN2ALOX15KDM4EPOLB | |
| SCHEMBL1905216 | 0.76 | SIGMAR1 (0.71) | ALDH1A1SMN1; SMN2GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170100490-A1 | Prodrug Comprising a Drug Linker Conjugate | ASCENDIS PHARMA A/S (DK) | 2017-04-13 | — | — | US | disclosed |
| US-20150057221-A1 | PRODRUG COMPRISING A DRUG LINKER CONJUGATE | ASCENDIS PHARMA AS (DK) | 2015-02-26 | — | — | US | disclosed |
| US-8906847-B2 | Prodrug comprising a drug linker conjugate | ASCENDIS PHARMA A/S (DK) | 2014-12-09 | — | — | US | disclosed |
| US-20110053848-A1 | PRODRUG COMPRISING A DRUG LINKER CONJUGATE | ASCENDIS PHARMA AS (DK) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057221-A1 | PRODRUG COMPRISING A DRUG LINKER CONJUGATE | H1-0, H1-3, H1-2 | ALDH1A1 140/4885SMN1; SMN2 3213/4885GNAI3 3669/4885 |
| US-20170100490-A1 | Prodrug Comprising a Drug Linker Conjugate | H1-0, H1-3, H1-2 | ALDH1A1 140/4885SMN1; SMN2 3213/4885GNAI3 3669/4885 |
| US-20110053848-A1 | PRODRUG COMPRISING A DRUG LINKER CONJUGATE | H1-0, H1-3, H1-2 | ALDH1A1 141/4885SMN1; SMN2 3189/4885GNAI3 3684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.