Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884840 | 0.82 | CA1 (0.40) | IDO1TDO2CA1CA2ALDH1A1 | |
| SCHEMBL1044702 | 0.80 | CA1 (0.48) | APLNRCA1CA2ALDH1A1CA12 | |
| SCHEMBL11164530 | 0.80 | CA2 (0.44) | CA1CA2ALDH1A1HTTCA12 | |
| SCHEMBL778325 | 0.78 | HTT (0.40) | IDO1TDO2CA1CA2ALDH1A1 | |
| SCHEMBL1792962 | 0.77 | PTGES2 (0.44) | CA1CA2ALDH1A1CA12CA9 | |
| SCHEMBL18028786 | 0.77 | PTGES2 (0.44) | CA1CA2ALDH1A1CA12CA9 | |
| SCHEMBL18028833 | 0.77 | PTGES2 (0.44) | CA1CA2ALDH1A1CA12CA9 | |
| SCHEMBL18471283 | 0.76 | APLNR (0.59) | APLNRIDO1TDO2ALDH1A1AOC3 | |
| SCHEMBL18471282 | 0.76 | APLNR (0.59) | APLNRIDO1TDO2ALDH1A1AOC3 | |
| SCHEMBL18471281 | 0.76 | APLNR (0.59) | APLNRIDO1TDO2ALDH1A1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940835-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007036733-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |