Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8672684 | 0.84 | ALDH1A1 (0.32) | DAOALDH1A1 | |
| SCHEMBL11788283 | 0.81 | LMNA (0.43) | DAOALDH1A1POLBHPGDNPC1 | |
| SCHEMBL1937347 | 0.81 | DAO (0.48) | DAOALDH1A1POLBHPGDCASP3 | |
| SCHEMBL25352415 | 0.79 | DAO (0.42) | DAOALDH1A1POLBHPGDCASP3 | |
| SCHEMBL10740706 | 0.78 | KMT2A (0.42) | DAOALDH1A1POLBHPGDCASP3 | |
| SCHEMBL9574960 | 0.78 | DAO (0.41) | DAOALDH1A1POLBHPGDNPC1 | |
| SCHEMBL1024697 | 0.77 | F2 (0.43) | DAOALDH1A1POLBHPGDCASP3 | |
| SCHEMBL9817948 | 0.75 | CES2 (0.43) | DAOALDH1A1POLBHPGDNPC1 | |
| SCHEMBL20357540 | 0.73 | DAO (0.37) | DAOALDH1A1POLBHPGDNPC1 | |
| SCHEMBL6678662 | 0.69 | MAPT (0.39) | ALDH1A1POLBCASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709043-B1 | PYRROLOPYRIDINE-SUBSTITUTED BENZOL DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1709043-A1 | PYRROLOPYRIDINE-SUBSTITUTED BENZOL DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005058891-A1 | PYRROLOPYRIDINE-SUBSTITUTED BENZOL DERIVATIVES FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-06-30 | — | — | WO | disclosed |
| EP-0599203-A1 | N,N-disubstituted arylcycloacrylamines, their salts, medicines containing these compounds and their use as well as processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-06-01 | — | — | EP | disclosed |
| EP-0098486-B1 | QUINOLINE DERIVATIVES, METHOD FOR THEIR PREPARATION, MICROBICIDES CONTAINING THEM, AND THEIR USE IN COMBATING FUNGI | BASF Aktiengesellschaft (DE) | 1986-09-03 | — | — | EP | disclosed |
| EP-0098486-A1 | Quinoline derivatives, method for their preparation, microbicides containing them, and their use in combating fungi | BASF Aktiengesellschaft (DE) | 1984-01-18 | — | — | EP | disclosed |