SCHEMBL4769781

SCHEMBL4769781

COCC[CH]c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TRPA1 O75762 2/20 0.39
ALDH1A1 P00352 2/20 0.39
CYP2A6 P11509 1/20 0.39
CA2 P00918 1/20 0.38
KDM4E B2RXH2 2/20 0.37
NPC1 O15118 2/20 0.37
GLA P06280 2/20 0.37
GAA P10253 2/20 0.37
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
LMNA P02545 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
RXFP1 Q9HBX9 1/20 0.35
TSHR P16473 2/20 0.35
RELA Q04206 1/20 0.35
NFE2L2 Q16236 1/20 0.35
NR1I2 O75469 1/20 0.35
PTGER4 P35408 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10883844 0.85 MEN1 (0.42) MEN1KMT2ATRPA1ALDH1A1CYP2A6
SCHEMBL10856149 0.78 RELA (0.41) MEN1KMT2AALDH1A1CYP2A6KDM4E
SCHEMBL10889497 0.78 ALDH1A1 (0.54) TRPA1ALDH1A1CYP2A6CA2KDM4E
SCHEMBL10888784 0.78 HSD17B10 (0.43) ALDH1A1CYP2A6KDM4ELMNAL3MBTL1
SCHEMBL15907605 0.78 MEN1 (0.61) MEN1KMT2ATRPA1ALDH1A1KDM4E
SCHEMBL2153833 0.78 NFE2L2 (0.44) MEN1KMT2ATRPA1ALDH1A1GAA
SCHEMBL6846168 0.78 MAPT (0.40) MEN1KMT2AALDH1A1CYP2A6KDM4E
SCHEMBL10887803 0.78 SMN1; SMN2 (0.42) MEN1KMT2AALDH1A1KDM4ENPC1
SCHEMBL18237170 0.77 MEN1 (0.42) MEN1KMT2ATRPA1ALDH1A1CYP2A6
SCHEMBL8709577 0.77 LSS (0.38) MEN1KMT2AKDM4EGAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963319-A1 HETEROARYLPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS Nerviano Medical Sciences S.r.l. (IT) 2008-09-03 EP disclosed
WO-2007071621-A1 HETEROARYLPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-06-28 WO disclosed
WO-2007068728-A2 N-SUBSTITUTED PYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS PFIZER ITALIA SRL (IT) 2007-06-21 WO disclosed
EP-1660085-A1 PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2006-05-31 EP disclosed
EP-1660475-A1 PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2006-05-31 EP disclosed
WO-2005013986-A1 PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS PHARMACIA ITALIA S.P.A. (IT) 2005-02-17 WO disclosed
WO-2005014572-A1 PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS PHARMACIA ITALIA S.P.A. (IT) 2005-02-17 WO disclosed
WO-2001020995-A9 COMPOUNDS DIRECTED AGAINST PILUS BIOGENESIS AND ACTIVITY IN PATHOGENIC BACTERIA; METHODS AND COMPOSITIONS FOR SYNTHESIS THEREOF UNIV WASHINGTON (US) 2002-11-14 WO disclosed
US-4598155-A 3(5-tetrazolyl)1,4-diaminoanthraquinones CIBA-GEIGY CORPORATION (US) 1986-07-01 US disclosed
US-4576753-A MICROBIOCIDES, ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1986-03-18 US disclosed
EP-0079862-B1 1,4-DIAMINO-ANTHRAQUINONE COMPOUNDS CIBA-GEIGY AG (CH) 1986-01-15 EP disclosed
US-4472309-A ANTIMICROBIAL FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-09-18 US disclosed
EP-0079862-A2 1,4-Diamino-anthraquinone compounds CIBA-GEIGY AG (CH) 1983-05-25 EP disclosed
US-4304718-A ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-12-08 US disclosed
US-4264498-A REACTED WITH AN ACID, ITS ACID HALIDE, OR ANHYDRIDE IN THE PRESENCE OF BORON TRIHALIDE AND AN ORGANIC BASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-04-28 US disclosed
US-4181800-A ANTIBIOTICS FROM SUBSTITUTED PERHYDRO-S-TRIAZINES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-01-01 US disclosed
US-4055428-A COLO PHOTOGRAPHY, DIFFUSION TRANSFER SILVER HALIDE EMULSIONS FUJI PHOTO FILM CO., LTD. (JA) 1977-10-25 US disclosed