Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 11/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778022 | 0.89 | P2RX7 (0.39) | LMNATP53MAPK1NPSR1P2RX7 | |
| SCHEMBL4777997 | 0.89 | TSHR (0.39) | LMNATP53MAPTBRD9P2RX7 | |
| SCHEMBL4525470 | 0.84 | MAPK1 (0.44) | LMNATP53MAPTMAPK1NPSR1 | |
| SCHEMBL4776024 | 0.82 | POLB (0.38) | LMNATP53MAPTBRD9MAOB | |
| SCHEMBL4767309 | 0.79 | BRD9 (0.35) | TP53MAPTBRD9HTT | |
| SCHEMBL4521143 | 0.78 | MAPK1 (0.44) | LMNATP53MAPTMAPK1NPSR1 | |
| SCHEMBL4772408 | 0.78 | TRPV4 (0.33) | LMNATP53MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL4772515 | 0.77 | KMT2A (0.38) | LMNATP53MAPTMAPK1NPSR1 | |
| SCHEMBL4522019 | 0.77 | MAPK14 (0.36) | LMNATP53MAPTMAPK1NPSR1 | |
| SCHEMBL4777218 | 0.77 | CYP2C19 (0.33) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |