Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524591 | 0.84 | POLB (0.36) | BRD9MPOMETTP53MAPT | |
| SCHEMBL4777218 | 0.83 | CYP2C19 (0.33) | GRM1 | |
| SCHEMBL4776024 | 0.82 | POLB (0.38) | BRD9TP53MAPTHTTPDE4B | |
| SCHEMBL4777997 | 0.81 | TSHR (0.39) | BRD9TP53MAPT | |
| SCHEMBL4511040 | 0.80 | LMNA (0.36) | BRD9MPOMAPTGRM1 | |
| SCHEMBL4769786 | 0.79 | LMNA (0.41) | BRD9TP53MAPTHTT | |
| SCHEMBL4513062 | 0.78 | DRD1 (0.36) | BRD9METTP53MAPTHTT | |
| SCHEMBL4778022 | 0.76 | P2RX7 (0.39) | TP53HTT | |
| SCHEMBL4772408 | 0.76 | TRPV4 (0.33) | MPOTP53 | |
| SCHEMBL4526123 | 0.76 | TSHR (0.35) | BRD9TP53MAPTHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |