Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574294 | 0.95 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTLMNAALDH1A1HPGD | |
| SCHEMBL4773504 | 0.81 | MAPT (0.45) | SMN1; SMN2MAPTLMNAALDH1A1CYP3A4 | |
| SCHEMBL4776209 | 0.79 | LMNA (0.41) | SMN1; SMN2MAPTLMNAALDH1A1HPGD | |
| SCHEMBL4773953 | 0.78 | POLB (0.40) | SMN1; SMN2MAPTALDH1A1CYP3A4MEN1 | |
| SCHEMBL212307 | 0.77 | EGFR (0.60) | SMN1; SMN2MAPTLMNAALDH1A1HPGD | |
| SCHEMBL843365 | 0.76 | TSHR (0.42) | SMN1; SMN2MAPTALDH1A1MAPK1POLB | |
| SCHEMBL4775893 | 0.76 | MAPT (0.48) | SMN1; SMN2MAPTLMNAALDH1A1CYP3A4 | |
| SCHEMBL13527456 | 0.74 | POLB (0.42) | SMN1; SMN2MAPTLMNAALDH1A1HTT | |
| SCHEMBL27614131 | 0.74 | MAPT (0.43) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2572685 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987030-A1 | 3 -DEAZAPURINE DERIVATIVES AS TLR7 MODULATORS | Pfizer Limited (GB) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093901-A1 | 3 -DEAZAPURINE DERIVATIVES AS TLR7 MODULATORS | PFIZER LIMITED (GB) | 2007-08-23 | — | — | WO | disclosed |