Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636286 | 0.99 | L3MBTL1 (0.74) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL4769081 | 0.91 | SIGMAR1 (0.74) | L3MBTL1MBTD1SIGMAR1KMT2ACYP3A4 | |
| SCHEMBL5438202 | 0.90 | SIGMAR1 (0.73) | L3MBTL1MBTD1SIGMAR1KMT2ACYP3A4 | |
| SCHEMBL3327029 | 0.89 | L3MBTL1 (0.72) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| Hydrochloric Acid SCHEMBL10853327 | 0.88 | SIGMAR1 (0.71) | L3MBTL1MBTD1SIGMAR1KMT2ACYP3A4 | |
| SCHEMBL3322160 | 0.87 | L3MBTL1 (0.74) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL9885409 | 0.86 | KMT2A (0.76) | L3MBTL1MBTD1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL14039394 | 0.86 | L3MBTL1 (0.97) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL14132491 | 0.85 | L3MBTL1 (0.71) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL23682795 | 0.84 | L3MBTL1 (1.00) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |