Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.74 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770184 | 0.99 | L3MBTL1 (0.72) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL5438202 | 0.91 | SIGMAR1 (0.73) | L3MBTL1MBTD1SIGMAR1KMT2ACYP3A4 | |
| SCHEMBL4769081 | 0.90 | SIGMAR1 (0.74) | L3MBTL1MBTD1SIGMAR1KMT2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL10853327 | 0.90 | SIGMAR1 (0.71) | L3MBTL1MBTD1SIGMAR1KMT2ACYP3A4 | |
| SCHEMBL3322160 | 0.88 | L3MBTL1 (0.74) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL9885409 | 0.87 | KMT2A (0.76) | L3MBTL1MBTD1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL3327029 | 0.87 | L3MBTL1 (0.72) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL23682795 | 0.85 | L3MBTL1 (1.00) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL10854490 | 0.85 | SIGMAR1 (0.83) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 | |
| SCHEMBL6034608 | 0.85 | SIGMAR1 (0.83) | L3MBTL1MBTD1SIGMAR1KMT2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543376-A1 | Benzotriazine inhibitors of kinases | Targegen, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| EP-2004615-A2 | QUINAZOLINES FOR PDK1 INHIBITION | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007117607-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2007117607-A2 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048561-A1 | QUINAZOLINES FOR PDK1 INHIBITION | PDK1, PDK2, PDK3 | L3MBTL1 2418/4885MBTD1 2253/4885SIGMAR1 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.