Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | ETV6 | P41212 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775548 | 0.96 | LMNA (0.54) | LMNAPOLBBACE1BACE2HRH3 | |
| Trifluoroacetic Acid SCHEMBL4770781 | 0.83 | SLC2A1 (0.42) | SLC2A1HRH3 | |
| Trifluoroacetic Acid SCHEMBL4768548 | 0.83 | ALDH1A1 (0.64) | LMNASLC2A1HRH3ALDH1A1NPC1 | |
| Trifluoroacetic Acid SCHEMBL4764951 | 0.81 | HRH3 (0.47) | LMNASLC2A1HRH3ALDH1A1NPC1 | |
| Trifluoroacetic Acid SCHEMBL4765765 | 0.81 | TP53 (0.50) | LMNASLC2A1HRH3NPC1TP53 | |
| Trifluoroacetic Acid SCHEMBL4767895 | 0.80 | AURKA (0.50) | SLC2A1HRH3AXLNPC1TP53 | |
| Trifluoroacetic Acid SCHEMBL4765255 | 0.80 | SLC2A1 (0.43) | LMNASLC2A1HRH3ALDH1A1NPC1 | |
| Trifluoroacetic Acid SCHEMBL4766836 | 0.80 | SLC2A1 (0.44) | LMNAPOLBSLC2A1HRH3ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4774281 | 0.80 | SLC2A1 (0.58) | SLC2A1HRH3ALDH1A1NPC1TP53 | |
| SCHEMBL4768454 | 0.79 | DGAT1 (0.39) | SLC2A1HRH3ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | claimed |
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | LMNA 3210/4885POLB 4330/4885BACE1 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.