Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | MAX | P61244 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772304 | 0.86 | DYRK3 (0.68) | DYRK3NPSR1MAPTPTPN11CISD1 | |
| SCHEMBL4772766 | 0.85 | DYRK3 (0.69) | DYRK3NPSR1PTPN11MEN1KMT2A | |
| SCHEMBL13196740 | 0.83 | DYRK3 (0.76) | DYRK3NPSR1CNR1MAPTMEN1 | |
| SCHEMBL2787639 | 0.83 | DYRK3 (0.76) | DYRK3NPSR1CNR1MAPTMEN1 | |
| SCHEMBL2787640 | 0.83 | DYRK3 (0.76) | DYRK3NPSR1CNR1MAPTMEN1 | |
| SCHEMBL4770970 | 0.82 | DYRK3 (0.52) | DYRK3NPSR1MAPTPTPN11CISD1 | |
| SCHEMBL4770141 | 0.82 | MEN1 (0.56) | DYRK3NPSR1MAPTPTPN11MEN1 | |
| SCHEMBL4772146 | 0.82 | DYRK3 (0.54) | DYRK3CNR1PTPN11CISD1MEN1 | |
| SCHEMBL4775509 | 0.82 | DYRK3 (0.55) | DYRK3CNR1PTPN11CISD1MEN1 | |
| SCHEMBL4774341 | 0.82 | MAPT (0.64) | DYRK3NPSR1MAPTPTPN11CISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |